General English name: Apomorphine

Brand: APO-go

Application: Parkinson's disease


Apomorphine Drug Information

Contraindications to the use of apomorphine

Drug interaction of apomorphine

Tips to consider before taking apomorphine

Possible side effects of apomorphine

How to store apomorphine



Apomorphine Drug Information

Medication Information: Parkinson's disease is a disorder of the brain. Parkinson's disease affects the way the brain coordinates with muscle movements. In this disease, a number of brain cells in the brain are damaged and die. These brain cells (dopaminergic neurons) transmit the message to the spinal cord by producing a chemical called dopamine (the main neurotransmitter dopamine made by brain cells in the substantia nigra), and it is this message that controls the movement of the body's muscles. When these brain cells are damaged, the amount of dopamine produced decreases. The combination of a decrease in brain cells and low levels of dopamine in the cells of this part of the brain slows down and abnormal nerve messages to the muscles. These are the main symptoms of Parkinson's disease, namely stiffness, shaking (shaking) and slowness of movement.

Apomorphine is a dopamine receptor agonist, meaning that the drug apomorphine acts as a dopamine on similar receptors in the brain. In fact, it acts as a substitute for dopamine, which helps reduce the symptoms of Parkinson's disease. Some patients with Parkinson's develop a type of Parkinson's disease when their disease progresses, in which it is sometimes easy for them to move and in a few minutes later they have difficulty moving, a condition called "on-off."

Apomorphine can reverse the "on-off" state of the disease, but the effect lasts for an hour, and since apomorphine must be injected subcutaneously, continuous injections are needed. For this reason, apomorphine is sometimes given as a continuous infusion (continuous injection), in which a tube with a needle at the end (called a cannula) is inserted under the skin. Apomorphine is prescribed by a specialist for Parkinson's patients, and the first dose of apomorphine should be given to you in a hospital under the supervision of a doctor.


Contraindications to the use of apomorphine

Treatment with apomorphine should be started in a hospital.

 Pay attention to the expiration date of the medicine and do not take it if the medicine in your hand has expired.

Never give the medicine to anyone else, even if you have the same symptoms.

 Do not take more than the dose prescribed by your doctor.

Check for drug interactions and be sure to tell your doctor what other medications you are taking.


Drug interaction of apomorphine

It may alter the performance of medications and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with apomorphine include:

Alosterone, antipsychotic drugs (eg, chlorpromazine), haloperidol, thiothixene, specific nausea drugs (eg, metoclopramide), phenothiazines such as phenothiazine Serotonin reuptake inhibitors such as ondansetron, granisetron, antihypertensive drugs (eg, beta blockers such as atenolol), vasodilators (eg nitrates), Water ”(diuretics such as furosemide, thiazides).

Many medications, along with apomorphine, may affect heart rhythm (prolongation of QT time), including:

Amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin).

If you have medications that cause drowsiness, including alcohol, antihistamines (such as cetirizine, diphenhydramine), sleeping pills or anxiety medications (such as alprazolam), diazepidam, zazepam Tell your doctor or pharmacist if you are taking muscle relaxants (such as carisoprodol), cyclobenzaprine and analgesics (such as codeine, hydrocodone).

Check the labels on all your medicines (such as cough and cold medicines, slimming medicines, nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen) because they may contain ingredients that increase blood pressure or worsen heart failure. Talk to your pharmacist about taking this medicine.


Tips to consider before taking apomorphine

Some medications are not suitable for people with certain conditions, and some medications may be prescribed if additional treatment is needed. Therefore, it is best for your doctor to be aware of the following before taking apomorphine:

  •  If you are unable to move or have involuntary movements when the "on-off" disease is on.
  •  If you have any breathing problems.
  •  If you have cardiovascular disease.
  •  If you feel dizzy when you stand because of low blood pressure.
  •  If you have any kidney or liver disease.
  •  If you have any mental health problems (such as insanity or dementia).
  •  If you are pregnant or breastfeeding your baby.
  •  If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
  •  If you have a history of an allergic reaction to a drug.


Possible side effects of apomorphine

All medications can cause side effects. But many consumers also do not experience any side effects. Some side effects go away shortly after taking the medicine. If any of the side effects persist, your doctor should be informed:

Feeling sick, feeling drowsy, small lumps, tenderness and redness at the injection site, feeling dizzy, feeling light in the head, yawning, dizziness, hallucinations

Important Note: If you notice any of the following severe symptoms after taking apomorphine, talk to your doctor as soon as possible:

Behavior change: including a desire to gamble or increase sexual desire.

Falling asleep suddenly: This is very important because you should not drive in such situations.


How to store apomorphine

 Keep all medicines out of the reach of children.

 Keep the medicine in a cool, dry place away from heat and direct sunlight.

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