General English name: Clomipramine

Application: Treatment of depression, obsession and fear - animal sleep in connection with sleep attack






Clomipramine Drug Information

Contraindications to clomipramine

Clomipramine drug interaction

Tips to consider before taking clomipramine

Possible side effects of clomipramine

How to store clomipramine






Clomipramine Drug Information

Drug Information: Clomipramine belongs to a group of drugs called tricyclic antidepressants. This drug helps reduce the symptoms of a number of diseases.

Depression: The exact cause of depression is not known. It can be caused by any obvious cause or event in life, such as a relationship problem, death, or a specific illness. Depression can cause you to constantly have a bad mood and also cause other symptoms that interfere with your daily activities.

Fear and obsession: Fear or phobia is a great fear of something or an event that is beyond the reality of the situation. An obsession is an unpleasant thought, image, or insistence that comes to your mind. Both of these diseases can make you feel anxious and prevent you from doing your normal activities.

Animal sleep related to sleep attack: Sleep attack is a long-term problem that affects sleep. This disease is often associated with a disease called animal sleep. Animal sleep is a term used to describe a sudden loss of muscle control, often triggered by a feeling such as anger or excitement. This disease causes you to drop something or stumble.

Clomipramine can help reduce the symptoms of any of these conditions. The drug is thought to work by interfering with brain chemicals (such as serotonin) that may be involved in causing symptoms.


Contraindications to clomipramine

• Clomipramine is hypnotic, do not drive while taking the drug.

Pay attention to the expiration date of clomipramine and do not take it if your medicine has expired.

Never give clomipramine to anyone else, even if you have the same symptoms.

• Do not take clomipramine more than the dose prescribed by your doctor.

Check for clomipramine drug interactions and be sure to tell your doctor what other medications you are taking.


Clomipramine drug interaction

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with clomipramine include anticholinergics (eg, atropine, belladonna alkaloids, scopolamine), antihypertensive drugs (eg, clonidine, guanethidine), reserpine. Cisapride, digoxin, thyroid supplements, valproic acid, drugs that can cause bleeding / bruising (for example, "blood thinners" such as warfarin / heparin, antiplatelet drugs such as aspirin, or NSAIDs such as ibuprofen).

If you take serotonin-boosting drugs in combination with clomipramine, your risk of serotonin toxicity increases. Tell your doctor if you are using these referees. These include: street medications such as MDMA / "ecstasy", St. John's wort, specific antidepressants (including SSRIs such as fluoxetine / paroxetine, SNRIs such as duloxetine / venlafaxine). Keep in mind that the risk of serotonin toxicity syndrome increases when you increase the dose of these drugs or start using these drugs.

Drugs that can affect the elimination of clomipramine from the body and its function include: alcohol, barbiturates (such as phenobarbital), cimetidine, haloperidol, specific heart rhythm drugs (such as flecainide / propafenone), and protease inhibitors (such as fos ampavir) Phenothiazines (such as thioridazine), some anticonvulsants (such as carbamazepine / phenytoin), terbinafine.

Avoid concomitant use of MAO inhibitors with MAO inhibitors, as MAO inhibitors may cause serious (possibly fatal) interactions. MAO inhibitors such as: isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine.

In addition to clomipramine, many medications may affect heart rhythm (prolongation of QT time), including: amiodarone, moxifloxacin, procainamide, quinidine, sotalol ); Therefore, before using clomipramine, make a list of all the medications you are taking and share it with your doctor and pharmacist.

Concomitant use of clomipramine with a number of medications may increase the risk of seizures, including isoniazid (INH), phenothiazines (eg, thioridazine), theophylline, or tricyclic antidepressants (eg, desipramine). .

If medications or sleeping pills such as alcohol, certain antihistamines (such as cetirizine, diphenhydramine), sleeping pills or anxiolytics (such as diazepam and zolpidem), muscle relaxants and painkillers, and painkillers. Be sure to tell your doctor if you are taking codeine.

Check the labels on all your medicines, especially painkillers or antipyretics (such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and naproxen), as taking them together with clomipramine increases the risk of bleeding. Be sure to take this medicine if you have been prescribed a low-dose aspirin (usually 325-81 mg per day) to prevent a heart attack or stroke. Be sure to talk to your pharmacist about taking this medicine with other medicines.

Check the labels on all your medicines (such as cough and cold medicines); Because they may contain hypnotic and anticonvulsant ingredients that increase blood pressure and heart rate. Talk to your pharmacist about taking clomipramine.

Smoking lowers blood levels of clomipramine. Tell your doctor Tell your doctor if you are smoking or have recently stopped smoking.


Tips to consider before taking clomipramine

Some medications are not suitable for people with certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking clomipramine:

• If you are pregnant or breast-feeding.

• If you have an overactive thyroid gland.

• If you have a liver problem.

• If you have epilepsy or diabetes mellitus.

• If you have had constipation for a long time.

• If you have trouble urinating or prostating.

• If you have a cardiovascular problem.

• If you have a mental health problem (specifically, bipolar disorder or psychosis).

• If you have glaucoma (increased pressure in the eye).

• If you have been told that you have pheochromocytoma (a tumor in the adrenal gland).

• If you have porphyria (a rare inherited blood disorder).

• If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines. Especially if you have recently taken antidepressants such as monoamine oxidase inhibitors (MAOIs).

• If you have a history of an allergic reaction to a drug.


Possible side effects of clomipramine

All medications can cause side effects; But many consumers do not experience any side effects. Some of the side effects go away after a short time of taking the medicine. In case of persistent side effects, the doctor should be informed:

Dry mouth, constipation, blurred vision, drowsiness, dizziness or tiredness, headache, sickness, diarrhea, weakness or dizziness, especially when getting up from a sitting or lying position, changes in blood test results such as ECG changes, sweating, hot flashes Problems with urination, Increased appetite, Wrong feeling, Feeling anxious and restless, Sleep disturbance, Concentration, Shivering, Muscle weakness, Itchy skin rash, Weight change, Changes in sexual function, Breast tenderness, Changes in taste, Ear ringing, yawning

Talk to your doctor if you have any symptoms that you think may be due to clomipramine.


How to store clomipramine

• Keep all medicines out of the reach of children.

• Keep the medicine in a cool, dry place away from heat and direct sunlight.

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