Brand: Sustiva

Application: Human Acquired Immune Deficiency Virus (HIV) Infection in Adults and Children Over 3 Years Old




Effervescent drug information

Contraindications to the use of efavirenz

Drug interference of efavirenz

Tips to consider before taking efavirenz

Possible side effects of efavirenz

How to store efavirenz






Effervescent drug information

Drug Information: Afavirenz is an antiretroviral drug used for Acquired Immune Deficiency Virus (HIV). Efavirenz reduces the progression of HIV infection but is not a definitive cure. HIV kills CD4 cells in the body. These cells are a type of white blood cell that is important in protecting the body against various infections. If left untreated, HIV will gradually weaken the body's immune system and the body will no longer be able to defend itself against bacteria, viruses and other germs.

Afavirins belong to a group of antiviral drugs called non-nucleoside reverse transcriptase inhibitors. Efavirenz is prescribed in combination with other antiretroviral drugs as a combination therapy. Taking several antiviral drugs at the same time is more effective than taking just one antiviral drug. This type of treatment also reduces the risk of virus resistance to the drugs.

Effervescence reduces the progression of HIV infection by reducing the multiplication of the virus in the blood. This mechanism strengthens the immune system and reduces the risk of HIV-related infections. Afavirenz is prescribed by specialist doctors.


Contraindications to the use of efavirenz

  • Pay attention to the expiration date of the medicine and do not take it if the medicine in your hand has expired.
  • Never give the medicine to anyone else, even if you have the same symptoms.
  • Do not take more than the dose prescribed by your doctor.
  • Check for drug interactions and be sure to tell your doctor what other medications you are taking.


Drug interference of efavirenz

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal products) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Drugs that may interact with efavirenz are: Specific combination products used to treat chronic hepatitis C (eg, Ambitasir, Ritonavir / Dasabovir).

Do not use efavirenz with medicines containing efavirenz unless your doctor prescribes these medicines.

Drugs that also affect the elimination of efavirenz from the body and the function of efavirenz include: specific rifamycins (such as rifampin), rifapentine, St. John's wort, anticonvulsants (such as carbamazepine, phenytoin).

Efavirenz can affect the elimination rate and performance of other drugs. Some of the drugs that are affected by efavirenz are: atovacone / proguanil, azole antifungals (such as itraconazole, ketoconazole), bedaquiline, calcium channel blockers (such as diltiazem, verapamil), antibiotics, methabiotroids (methabiotroids). Rifabutin, sertraline, some cholesterol-lowering drugs (statins) (such as atorvastatin, pravastatin, simvastatin), specific protease inhibitors (such as boceprevir, simeprevir), warfarin.

Some other HIV medications (such as rilpivirine, norepinephrine, etravirine) may also interact with efavirenz. If you are taking atazanavir with these medicines, you may need to take another medicine (ritonavir). Consult your doctor or pharmacist for more details about taking these medications.

Efavirenz may reduce the effectiveness of hormonal contraceptives such as pills, patches, or rings. This can lead to pregnancy. Talk to your doctor about a reliable way to control pregnancy, and use an effective method (latex condom or polyurethane) throughout your sexual activity to reduce the risk of spreading HIV to others. If you have spotting or heavy bleeding, talk to your doctor. Talk about it, because it may be a sign that your hormonal pregnancy control is not working well.

If you are taking medicines that cause drowsiness, tell your doctor or pharmacist, including: alcohol, antihistamines (such as cetirizine, diphenhydramine), sleeping pills or anti-anxiety medications (such as alprazolam), alprazolam (alprazolam) Diazepam, zolpidem, muscle relaxants, and painkillers (such as codeine).

Check the labels on all your medicines (such as allergies or cough and cold medicines) because some of them are made up of substances that cause drowsiness. Ask your pharmacist how to use them so that you can use them safely.

Afavirenz may interfere with certain tests (including urine cannabinoid tests) and may result in erroneous test results. Be sure to tell your doctor and lab staff that you have used efavirenz before performing the test.


Tips to consider before taking efavirenz

Some medications can not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed. Therefore, it is best for your doctor to be aware of the following before taking efavirenz:

  • If you decide to have a baby, if you are pregnant, or if you are breast-feeding.
  • If you have liver or kidney problems.
  • If you have ever had a mental health problem.
  • If you have ever had a seizure. If you have porphyria (a rare blood disorder).
  • If you are currently taking certain medications. These include all available medicines, whether prescribed or used by your doctor, such as herbal medicines and supplements.
  • If you have ever been allergic to a particular medicine.


Possible side effects of efavirenz

All medications, along with their positive effects, can cause unwanted side effects in the body. However, these complications do not occur in all people. Over time, your body will adjust to the new medicine and these symptoms will go away, but if the following symptoms persist or become painful, consult your doctor.

About 1 in 10 patients who take efavirenz may typically experience the following side effects:

  • Itchy urticaria (usually during the first week): Tell your doctor immediately if the urticaria is severe.
  • Diarrhea: Drink plenty of water to replenish lost water.
  • Feeling sick, stomach ache: Eat simple foods - Avoid high-fat and spicy foods. Tell your doctor if these cases become severe or persist.
  • Headache: Ask your doctor to prescribe a suitable painkiller.
  • Fatigue and weakness: Avoid driving and working with tools at this time.
  • Anxiety and depression: Tell your doctor.
  • Sleep disorders, decreased concentration: These symptoms usually improve after a week.
  • Changes in blood test results: Your doctor will evaluate these items.

Talk to your doctor if you have any other symptoms that you feel may be due to the medication efavirenz.


How to store efavirenz

  • Keep all medicines out of the reach of children.
  • Keep the medicine in a cool, dry place away from heat and direct sunlight.
  • After opening in Sustiva syrup for 30 days, this medicine can be used. After this period, buy a new medicine.
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