Neostigmine

 

General English name: Neostigmine

Application: Myasthenia gravis

 

 

 

 

 

 

Medicinal forms of neostigmine

Neostigmine Drug Information

Amount and method of neostigmine use

Contraindications Neostigmine

Neostigmine use during pregnancy and lactation

The effect of neostigmine on driving and working with machines

Neostigmine drug interactions

Special warnings and precautions while taking Neostigmine

Side effects of neostigmine

Neostigmine overdose (drug poisoning)

Storage conditions of neostigmine

 

 

 

 

 

 

 

Medicinal forms of neostigmine

Tablet

 

Neostigmine Drug Information

Neostigmine is prescribed for myasthenia gravis. Myasthenia gravis is a disease that causes muscle fatigue and weakness. This condition causes problems with the transmission of nerve signals from the nerves to your muscles, which prevents your muscles from stimulating and contracting properly. In this disease, the muscles around the eyes are initially affected. Myasthenia gravis is an autoimmune disease. This means that the immune system (which usually protects your body from infection) mistakenly attacks itself.

Your brain normally sends messages to the muscles by releasing a chemical called acetylcholine from the nerve endings. Acetylcholine rapidly attaches to small areas on the muscles (acetylcholine receptors), causing the muscles to contract. In most people with myasthenia gravis, the immune system blocks or damages these acetylcholine receptors. Acetylcholine can no longer bind to its receptor and therefore the muscle is less able to tighten.

Neostigmine works by reducing the breakdown of acetylcholine when it is released from the nerve endings. This means that there is more acetylcholine to bind to muscle receptors, which increases the strength of your muscles.

 

Amount and method of neostigmine use

Read the package leaflet carefully before starting treatment with Neostigmine. This brochure will help you to get comprehensive information about the drug and its possible side effects.

The dose and amount of neostigmine varies from person to person depending on the disease; Use the medicine exactly as your doctor advised. The dose of this medicine should be taken exactly and according to the doctor's prescription. Neostigmine is usually given to adults 1-2 tablets several times a day. It takes 30-60 minutes for the tablets to start working and the effect lasts for about 4 hours. Take the pills at regular intervals (for example, early in the morning and before meals) when you are very active and need your muscles to be strong. When neostigmine is given to a child, the dose of the drug is calculated according to the age of the child.

Swallow the tablet with some water.

If you forget to take your daily dose at the right time, take it whenever you can; If you do not soon remember that you should take your medicine, do not take the missed dose. You should not take two doses of the medicine together because of the missed dose.

 

Contraindications Neostigmine

Note the expiration date of neostigmine and do not take it if it has expired.

Never give neostigmine to another person, even if you have the same symptoms.

Check for drug interactions, and if you are taking a drug that interacts with this medication, talk to your doctor about using your medications.

 

Neostigmine use during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily without consulting your doctor. Medications can have devastating effects on the fetus or on yourself.

 

The effect of neostigmine on driving and working with machines

Although this medicine does not make you drowsy, make sure you are alert before driving or operating machinery.

 

 Neostigmine drug interactions

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Tell your doctor for a list of all prescription or over-the-counter medications, especially medications such as aminoglycoside antibiotics (eg gentamicin), anti-arthritis medications (eg quinidine), or medications that reduce stomach movements. (Antihistamines such as diphenhydramine, antispasmodics such as dicyclomine, analgesics such as morphine)

 

Special warnings and precautions while taking Neostigmine

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best to let your doctor know the following before taking the medicine:

  • If you are pregnant or breast-feeding.
  • If you have any kidney problems.
  • If you have a heart problem such as a slow heartbeat or a history of heart attack.
  • If you have a condition such as epilepsy, Parkinson's, hyperthyroidism or difficulty urinating.
  • If you have asthma.
  • If you have a stomach ulcer.
  • If you feel that you have an intestinal obstruction.
  • If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
  • If you have a history of an allergic reaction to a drug.

 

Side effects of neostigmine

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away after a short time of taking the medicine. In case of persistent side effects, the physician should be informed:

Increased saliva

Diarrhea

Heartburn and intestinal cramps

Feeling sick, nauseous or vomiting

Consult your doctor if you have any other symptoms that you feel may be due to the use of neostigmine.

 

Neostigmine overdose (drug poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that someone has drug poisoning and symptoms such as nausea, vomiting, diarrhea, rapid or irregular heartbeat, dizziness, increased saliva and sweating, blinking, confusion, muscle cramps and weakness, inability to move, shortness of breath or fainting And if you see weakness in him, call the emergency room immediately.

 

Storage conditions of neostigmine

Keep the medicine out of the reach of children.

Store the medicine in a cool, dry place away from heat and direct sunlight.

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