Ondansetron
Brand: Demorem, Ondemet, Setofilm, Zofran
Application: Prevention or treatment of nausea associated with chemotherapy, radiation therapy or surgery
Ondansetron Pharmaceutical Information
Contraindications to the use of ondansetron
Ondansetron drug interaction
Tips to consider before taking ondansetron
Possible side effects of ondansetron
How to store ondansetron
Ondansetron Pharmaceutical Information
Drug Information: Ondansetron is known as a 5HT3 receptor antagonist. This medicine is prescribed to prevent you from feeling sick. Ondansetron works by blocking the action of a natural chemical in the body called serotonin. Also called serotonin 5HT.
Chemotherapy, radiation therapy, or surgery can increase the amount of serotonin secreted by the body. There are small receptors in the small intestine and brain called the 5HT3 receptor. Serotonin acts on these receptors and makes you feel sick. By blocking serotonin, ondansetron blocks its effect on 5HT3 receptors and eliminates the feeling of sickness and nausea.
Contraindications to the use of ondansetron
- Note the expiration date of ondansetron and do not take it if it has expired.
- Never give ondansetron to anyone else, even if you have the same symptoms.
- Do not take more than the dose of ondansetron prescribed by your doctor.
- Check for ondansetron drug interactions and be sure to tell your doctor what other medications you are taking.
Ondansetron drug interaction
Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter medicines and herbal medicines (especially tramadol)) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.
Do not use ondansetron in combination with apomorphine, as these two drugs have serious drug interactions. If you are currently taking apomorphine, tell your doctor before you start using ondansetron.
In addition to ondansetron, many drugs may affect heart rhythm (prolongation of QT time), including: amiodarone, moxifloxacin, procainamide, quinidine, sotalol ( sotalol), pimozide, and macrolide antibiotics (such as erythromycin). Therefore, before using ondansetron, make a list of all the medications you are taking and share it with your doctor and pharmacist.
If you take serotonin-boosting drugs in combination with ondansetron, your risk of serotonin toxicity increases. Tell your doctor if you are using these referees. These include: street medications such as MDMA / "ecstasy", St. John's wort, specific antidepressants (including SSRIs such as fluoxetine / paroxetine, SNRIs such as duloxetine / venlafaxine). Keep in mind that the risk of serotonin toxicity syndrome increases when you increase the dose of these drugs or start using these drugs.
Tips to consider before taking ondansetron
Some medications are not suitable for people with certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking ondansetron:
- If you are pregnant or breast-feeding.
- If you have severe intestinal obstruction or constipation.
- If you have any liver problems.
- If your heart rate is irregular.
- If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
- If you have a history of an allergic reaction to a drug.
Possible side effects of ondansetron
All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking ondansetron. In case of persistent side effects, the physician should be informed:
Common complications
Headache, constipation, feeling hot or stuffy
Rare complications
Hiccups, chest pain, slow heartbeat, dizziness when getting up, and unusual body movements
Consult your doctor if you have any other symptoms that you feel are due to the use of this medicine.
How to store ondansetron
- Keep all medicines out of the reach of children.
- Keep the medicine in a cool, dry place away from heat and direct sunlight.