probenecid

 

 

General English name: probenecid

Brand: Benemid

Application: Gout - Gouty arthritis

 

 

 

 

Dosage forms of probenecid

Probenecid drug information

The correct amount and method of taking probenecid

Contraindications to Probenecid

Probenecid during pregnancy and lactation

The effect of probenecid consumption on driving

Drug interaction Probenecid

Warning about taking probenecid

Side effects of probenecid

Complications of probenecid overdose (probenecid poisoning)

Storage conditions of probenecid

 

 

 

Dosage forms of probenecid

Tablet

 

Probenecid drug information

Gout causes painful inflammatory attacks in one or more joints. This process is caused by the accumulation of chemicals in the blood called uric acid. Sometimes the level of uric acid in the blood rises sharply and crystalline bodies form in the joints and tendons, these crystals irritate the muscle tissue resulting in inflammation, pain and swelling. Probenecid is used to prevent gout and malignant arthritis.

It is not used to treat a sudden, severe attack of gout, but it may make the condition worse. Probenecid belongs to a group of medicines called uricosuric drugs, which help the kidneys to excrete uric acid, reducing high levels of uric acid in the body; As a result, it helps treat gout.

Probenecid may be given in combination with some antibiotics (such as penicillins). It increases the level of antibiotics in the blood and helps antibiotics work better.

 

The correct amount and method of taking probenecid

  • Read the package leaflet carefully before starting treatment with this medicine. This brochure will help you to get information about the drug and its possible side effects.
  • The dose and amount of probenecid varies from person to person; Take one pill exactly as your doctor advised. You should usually start treatment with a low dose of this medicine and then adjust the dose of your medicine according to your symptoms. After a few months when your uric acid is normal, reduce your daily dose to the lowest effective dose.
  • You should not start taking this medicine with the onset of severe and sudden gout attacks. You need to wait until your severe gout symptoms subside and then take this medicine.
  • Probenecid is not a painkiller, you should use medications such as colchicine, indomethacin or naproxen to relieve muscle pain caused by gout.
  • If you forget to take your daily dose at the right time but soon forget to take it; But if you remember when the next dose is near the hour, do not take the missed dose. You should not take two doses of the medicine together because of the missed dose.

 

Contraindications to Probenecid

  • Pay attention to the expiration date of probenecid and do not take the medicine if it has expired.
  • Never give probenecid to another person, even if you have the same symptoms.
  • Check for drug interactions with probenecid, and if you are taking a drug that interacts with this drug, talk to your doctor about using your medications.
  • Probenecid tablets are contraindicated for children under 2 years of age.

 

Probenecid during pregnancy and lactation

During pregnancy and lactation, you should not use the drug arbitrarily without consulting your doctor. Medications can have devastating effects on the fetus or on yourself.

 

The effect of probenecid consumption on driving

Probenecid may confuse you, make sure you are alert before driving or operating machinery.

 

Drug interaction Probenecid

Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.

Some medications that may interact with probenecid include: Cancer chemotherapy drugs, ketorolac, dyphylline, methotrexate, pyrazinamide, salicylates (such as high-dose aspirin), zidovudine, certain drugs that are eliminated by the kidneys. (Such as ceftazidime / avibactam, dapsone, heparin, phosphomycin).

Probenecid may interfere with certain laboratory tests (urinary glucose levels) and cause erroneous results. Ask your doctor or nurse before taking the test if you can use this medicine.

 

 Warning about taking probenecid

Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to know the following before taking probenecid:

  • If you are pregnant or planning to become pregnant, or if you are breast-feeding.
  • If you have kidney or liver problems.
  • If you have a blood disorder or problem.
  • If you have kidney stones.
  • If you are consuming alcohol or drugs.
  • If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
  • If you have a history of an allergic reaction to a drug.

 

Side effects of probenecid

All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away shortly after taking this medicine. In case of persistent side effects, the doctor should be informed:

Nausea

Loss of appetite

Vertigo

Vomit

Headache

Wound pain

Frequent urination

Important Note: If you experience any of the following unusual but serious symptoms, stop taking probenecid and call your doctor right away for advice:

• If you have any breathing problems such as wheezing, shortness of breath.

• If you have any signs of an allergic reaction such as swelling around the mouth or face or itchy pimples.

• If the color or volume of your urine changes or your urination is accompanied by pain or problems.

Consult your doctor if you have any other symptoms that you feel may be due to probenecid.

 

Complications of probenecid overdose (probenecid poisoning)

Do not take more than the dose prescribed by your doctor.

If you feel that someone has been poisoned and you have symptoms such as severe nausea, shortness of breath, fainting and weakness (fainting), call the emergency room immediately.

 

Storage conditions of probenecid

Keep the medicine out of the reach of children.

Store the medicine in a cool, dry place away from heat and direct sunlight.

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